Amazon's entire system ran on a single Oracle cluster up until about 2008 (they were still at the tail end of phasing that out when I was there in 2012).
There are so many crazy tricks out there. You would be amazed at how much abuse an old school RDBMS engine can take on modern hardware. In-memory OLTP on servers that can host terabytes of RAM completely changes the game. Disaggregated compute & storage provides seamless OLAP capabilities on the same SQL connection instance for the most modern providers.
Really, as it pertains to this, it is a question of "where do I want to move the complexity to?", not "can I eliminate it?"