I asked an Iranian coworker if the Iranian government is serious or if it's just a bad translation when we hear them call America and Israel "the Great Satan". Apparently they are entirely sincere about that.
It seems like the main thing Iran has done against the US is through proxies, which reflects modern US strategy.
Having said that, it doesn't condone the actions of the Iranian regime as well.
Looking up the quote, Regan was talking about the USSR? If so I think it may be stronger than that sentiment, but I'm not 100% sure owing (in addition to the previous point about games of telephone) to not having lived through the worst of the Cold War — and the small bit I did live through before the USSR collapsed was entirely in the UK and my experience as a child contained more fear of the IRA than the USSR as the IRA were in the news while the USSR were, (like the Klingons that were a thin analogy for them), only in films and on TV.
US also helped current regime when it first gained power.