How could I control a screen like that with a Raspberry Pi?
Running in series with the regular adafruit library would work as well but at this number of pixels the refresh rate might start to get a bit choppy, and you probably want to add power in the middle of the string regardless so the wiring isn't any harder.
Then use a library on the pi, for example this: https://github.com/jgarff/rpi_ws281x