I'm adhering to Gmail inbox 20,000 at the moment, and it's... handling it (~3s search time)
Inbox 20,000 makes sense for a lot of people btw. Depends on your work and how important being organised with your email is to you.
Many people just declare email bankruptcy and don't care.
If you are on a very high number of emails, you can just archive the last 19,800 and go from there. And then unsubscribe from a lot of your key email offenders.