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> that really seems like a last resort

Have we had a compelling reason to research drugs whose primary purpose is to kill bone marrow in healthy patients before?

Several forms of immune system cancer treatment involve nuking the immune system and getting a bone marrow transplant from a healthy donor.

Leukemia for sure, and I think also a few kinds (or at least stages) of lymphoma.

Sure we have, melphalan is being used to treat multiple myeloma for decades now.

Kill all the cancer in your bone marrow and transplant new stem cells to regrow it.