One major gotcha they're still working on is PyQt support -- their introspection techniques tend to break very often when dealing with it, which results in a lot of unnecessary warnings and word-completion being spotty. I understand their main target market is web-developers (Django and GAE support looks good, now virtualenv is also dealt with in the proper way), but that's a niche that has been crying out loud for good tools for ages (ERIC is weak, sorry).