The GGUF handling for Mistral's mixture of experts hasn't been finalized yet. TheBloke and ggerganov and friends are still figuring out what works best.
The Q5_K_M gguf model is about 32GB. That's not going to fit into any consumer grade GPU, but it should be possible to run on a reasonably powerful workstation or gaming rig. Maybe not fast enough to be useful for everyday productivity, but it should run well enough to get a sense of what's possible. Sort of a glimpse into the future.