I use Emacs but I discovered to my surprise that the creator of Biff does not. I don't see a lot of Emacs specific stuff in the documentation.
I recommend the tutorial project (eelchat). Otherwise, they are really helpful in Slack... someone usually answers any issue in a couple of hours or much less.
What's most important is that Biff brought me was a working front-end out of the box that I could start tweaking right away. When I used Luminus I had more steps and they were really hard to figure out as a beginner. However, shout out for Luminus... it was my go-to before Biff and I have huge gratitude.
I didn't know about htmx and it has been a game changer. This is probably my favorite feature.
This was the first time I was able to fluidly get something going, tweak the backend and UI, and deploy. Other approaches had some but not all of those.
The deployment situation is a dream. It was incredible to have my site up with a few steps. For a less skilled developer like me this was totally awesome. Biff has a continous code-push/deploy feature that is incredible.
Sorry if this seems like a fanboy post. It's probably because for Biff I am one. My feeling is that for Clojure to grow userwise there need to be a lot more projects like this one.