I’ve had powerline adapters work quite happily sometimes (and unhappily other times) on separate circuits in my home so it clearly can tolerate some level of copper juncture (circuit breakers, consumer units, and the like) beyond a simple ring main.
A recent unit I bought had an optional pairing process between adapters. I don’t know how it works but it is billed as a way of ensuring privacy between endpoints. It wasn’t clear from the documentation if this was to protect me from other people in my house, or from neighbouring properties.