Perhaps the most impressive feat I've seen out of 2B2T was an exploit called "Nocom".
It began with 2B2T being hit with a lag exploit, then that exploit being fixed in a 3-line patch - that patch subtly introduced another exploit that allowed the author to track the position of every player in the server at all times, down to the chunk.
I won't explain the whole video[0], but it details a story of gaslighting, 3 years of player data, and some really really impressive technical work, given this is all over a block game.
[0] https://youtu.be/elqAh3GWRpA
And while certainly not to the scale of Minecraft, Counter-Strike does have a (diminishing) sizeable community of cheaters that majorly play against each other, competing in technique and configuration, called Hack-vs-Hack (HvH).