I do that, and I've even personally experienced a few rare ZFS bugs that seem due to interactions between ZFS and Western Digital firmwares.
Still, I was caught unprepared: I have several backups not stored on ZFS, but all of them were made FROM a ZFS source, meaning they are now all suspicious since silent corruption has been possible since version 2.1.4, and maybe even longer than that.
ZFS is practical to use, but for now I think I'll keep a history of file checksums, like how it was done before bitrot protection.
I'm also assuming those backups aren't actually ZFS streams (from zfs send|receive) which is a special case of "bugs biting you twice" :P
ZFS just is, no need to worry about layering device mappers and LVM. The automount is also very nice.