I love BBEdit, primarily because there is an actual user interface (and good documentation) for most of the features I use. I know that, in principle, anything is possible with emacs but in practice I always have trouble finding functionality.

I do have two constant annoyances with BBEdit, though. One is the syntax highlighting isn't as good out of the box as the competition. The other is that the tab key doesn't automagically indent my code like in emacs. I've given up hope on these features ever coming to BBEdit. After 20 years, if they're not there chances are good they never will be.