Generally, questions come in three classes: clarification ("I'm not sure I understand, can you explain..."), discussion ("Have you considered extending this to..."), and criticism ("I think there is a problem with this approach..."). In an academic setting, all are welcome unless otherwise stated. (Sometimes we say no discussion and critical questions because of time limitations.)
However, what is never acceptable is someone commandeering the presentation and using it to talk about their own thing. Moderators will step in if it starts devolving like that.
So, simply, you need to let your audience know what the format is, because had I been in your audience, I may have asked questions, too.