It’s just an observation that “if violence didn’t solve the problem, you weren’t using enough” is sometimes true with other things substituted for “violence”.
I think that’s a useful thought.
I think that’s a useful thought.
Drugs often have more than one active pharmaceutical ingredient in them. For example, rybelsis vs mounjaro. The average senior citizen is taking four medications.
Pase 1 trials test doses of therapeutics far above what ends up on the market. In general there is a trade off between safety and effectiveness. Note that safety is evaluated in the context of the underlying condition. So worse side effects are tolerable for treating something cancer or HIV, than for treating something like a common cold,
The drug in the example given by the author, Alopurinol, is very hepatotoxic so cranking up the dosage is not something you can do without risk of killing someone. Or you could just use rasburicase - recombinant urate-oxidase - instead.