I have the slightly newer version, branded by HP as the SpacePilot, and use it daily in Fusion 360 CAD. It has a native USB connection, and 6 user-definable hotkeys below an unimpressive LCD.

It requires some old drivers that aren't officially supported (why would they remove support for perfectly good hardware from the newer drivers? To send good stuff to the landfill, of course!), but when Autodesk tried to move Fusion to the new driver model exclusively, user outcry persuaded them to leave the old drivers in as an option. Apparently there's quite a few of us using those SpacePilots, and the phrase "from my cold, dead fingers" comes up not infrequently.