Django for most (if not all) of the server-side code, Django templates generating HTML, htmx handling most interactivity with html attributes and, when necessary, hyperscript (for use cases that can’t be covered easily by htmx). I would probably stick with downloading minified Bootstrap for styling (Tailwind requires a build step, and I don’t think I have done well in the past when I waded into “class soup”).
Has anyone here tried something along these lines for a non-trivial app? How is it going?