It definitely looks nice, but like qhoxie says, I don't see anything extremely compelling about this vs. the dozens of other list sites out there.

No nested items, no syncing, what is the real advantage to using this over using Remember the Milk or something else?

You don't need a ton of killer features to differentiate it, but one is a minimum.

I was excited for the twitter integration until I tried to figure out how it worked and was met with "email us because regular people are not worthy" note on the blog. Not helpful. Is it that much work to write a blog post explaining how it works and then link it next to the twitter setup field in the preferences?

Came here to mention those two points. Excellent job. FYI though, the big image above the sign up and tour buttons didn't appear until I disabled Safari AdBlock.

"What sets this apart?" Right now I do agree with this statement and it definitely needs to be addressed. Do you (or anyone) have any needs that aren't currently addressed by other to-do list applications?

I want what sets this apart to be something that is actually useful (instead of a neat looking but pointless gimmick).