Just check the keybindings of anything eval in SLIME for a Lisp file buffer:
C-x C-e
C-M-x
C-c C-p
C-C C-r
C-c :
Evaluation of Lisp code is central to Lisp. But the keybindings are just awful. Generally getting rid of one layer of prefix keys would be a start.GNU Emacs also still believes that my Mac has a Meta and a Super key. It hasn't. Every new user has to learn keys which are not labelled on any typical keyboard produced in the last 30 years.
My Lisp Machine keyboards from the 1980s have Meta, Super, Hyper keys, though.