1. Energy loss from neutron loss. So-called "aneutronic fusion" seeks to avoid this problem but requires rare fuels (eg He-3), which kind of defeats the point. Also, it's not neutron free. It's just fewer neutrons;
2. Container destruction from neutrons (ie "neutron embrittlement"); and
3. A superheated plasma (in either a tokamak or stellerator) is fundamentally a turbulent fluid. This is inherently unstable. Any imperfection in the containment could result in significant container damage.
Fusion works for stars because fusion is relatively slow (on a per-unit mass basis, which is why stars can live billions or evne trillions of years) and they have gravity for neutron containment.
More on the difference to tokamaks [1].
[1]: https://www.sciencedirect.com/science/article/pii/S2468080X1...