Colemak (and in particular Colemak-DH) is a great layout and if you can just get past the painful learning process then you should see a sizeable comfort boost.

Now depending on your goals and preferences there might be other things you can try (which is outlined in the article). Using a more ergonomical keyboard for instance will probably give you more ergonomical benefits for less effort.

There are also tips for making the learning process more efficient in the article.