> Uniprot lists many/all of the genes/proteins that have been decoded so far. It's a bit odd to call that a "niche" in the context of the field of biology.

I actually checked uniprot, yes, it lists proteins (probably most of them), but ontology is raither narrow, it has few dozens properties, you can't for example query that DB with question: give me diseases which can be attributed to broken pathways synthesizing protein X, you would need to do a lot of manual work and check external databases of uncertain quality.

Another question is quality of that dataset, why it is so obvious that all those millions of pathways for hundreds thousands proteins are researched and described with 100% accuracy?