In my personal experience, I can't handle weed. It makes me paranoid. I tried a weekish ago to smoke a bit with some friends and while being high I remembered why I stopped years ago. My mind simply doesn't manage it very well. It makes me feel anxious and can't control negative thoughts (guilt, shame, mistakes etc not related with the action of consumption itself). I think we should avoid to fall into the "it's just a natural plant" fallacy I've personally heard many times.

Edit: Why the downvotes? I just mentioned a explicitly stated personal take related to the topic...