Real Estate. So many quirky things are viable when there's cheaper rent, cheap buying opportunities, or underutilized space. If I could buy space for $150/sq ft, I might have some extra cash, like the idea of investing in real estate, and like the idea of having a cool community hackerspace. If it's going to cost me $1,000/sq ft, I'm barely going to be able to afford the space I want to live in. If a group of us can rent at cheap prices we're saving money on our housing and paying for a shared second space doesn't cost that much.
Over the past 15 years or so, property prices have soared in so many cities. It really makes it hard to afford space for quirky things. There are certainly plenty of examples of ones that still exist and enough determination and you can still make things happen, but I think the rising cost of real estate is putting a damper on things like this.