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JMP is used industrially for design of experiments: https://www.jmp.com/en_us/software/capabilities/design-of-ex...

R also seems to have some libraries for things related to design of experiments.

JMP is also a very criminally underrated and flexible tool to do data analysis with – both exploratory and modelling. It's my preferred tool of choice over R, especially after they added a structural equation modelling platform.

It's a pity they got rid of pricy perpetual licensing quite a few years ago for a no less pricy subscription model.

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