Reading this made me really sad.
It's actually hard for me to conjure the strength to write and share an appropriate response, and explain why.
Let me just mention one of many thoughts. Mark Andreessen cites a number of Patron Saints of Techno-Optimism, "In lieu of detailed endnotes and citations, read the work of these people, and you too will become a Techno-Optimist."
One of them is Filippo Tommaso Marinetti.
This is what FTM writes in his Manifesto of Futurism [0]. (original Italian first, then English translation).
""Noi vogliamo glorificare la guerra - sola igiene del mondo - il militarismo, il patriottismo, il gesto distruttore dei liberatori, le belle idee per cui si muore e il disprezzo della donna."
"We will glorify war - the only true hygiene of the world - militarism, patriotism, the destructive gesture of anarchist, the beautiful ideas which kill, and the scorn of woman"
In 2023, reading about the "glory of war", and the "scorn of woman", should be enough to know what's needed to judge this guy.
Mark, you are really smart and successful and most people would envy your fame and wealth and intelligence, but you need to grow up for once and realize how sick some of your ideas are.