It's been a while since I saw Up, but isn't the moral of that movie that Carl is holding onto the past too tightly and that doing so has separated him from the outside world and the people around him and colored his perception of them? The emotional climax of the film is Carl throwing away all of his antique furniture that is metaphorically and literally weighing him down, and then the film ends by Carl dropping his house off of a blimp.
I do have sympathy, it's a understandable position for someone to be in, but I'm not sure that Up in specific is the best analogy?