Chemistry. Etching is not ideal process. In real life it not make ideally vertical hole, but it tends to go V-like or ^-like, so real mask will have artifacts, which are much narrower or much wider than considered, or sometimes could overlap.
This could been handled by careful selection of parameters - solution concentration, temperature, pressure, mechanical mixing, etc, but on each step of feature size, it become harder to achieve.
I have first education electronics engineer, and I seen broken PCBs, where these artifacts seen by naked eye.