Edit: Two takeaways I did enjoy (can't recall from which book):
Humans were pray animals that quickly became dominant predators, not allowing us to develop the confidence of "real" predators, so we are still scared of the dark and everything else.
Humans were able to stay in practically the same state for 40k years in Australia. After killing some megafauna of course. In the last 1k years, we've upset the apple cart and may destroy the world as we know and need it. We _can_ coexist in our environment without utterly destroying it in 40k years - but we are not.