Win - Alt - Ctrl - Space - Ctrl - Alt - Win
This is so that I can use my thumbs for Ctrl and index fingers for Alt. I taught myself to use the opposite side modifiers every time (using the right control for Ctrl-S).
This got rid of the vast majority of unergonomic keystrokes for me.
I know you can remap your keys but there's inertia to just go with what you're given.
I've also noticed myself switching between Mac, Windows, and Linux, that Cmd-C on my Mac is way less stressful on my hand than Ctrl-C on the other 2 machines. I should probably figure out how to remap those.
PS: If you're curious how emacs was forced, it was because the lead built the project's IDE/build/debugging system into emacs
Elegant.
And I mean for those two particular modifiers with that relationship, not just the idea in general.