The dominant paradigm (due to mastodon emulating twitter is the "timeline"). A major alternative mode of interacting with the fediverse could be a mailbox-like client.
Posts and threads of accounts and hashtags you follow would appear in the respective folders (boldface indicates new and unread).
The local and federated folders would offer the firehose view for those addicted to that.
In fact a sophisticated integrated client for email, rss and activitypub would be well placed to empower users manage their interaction with a re-decentralized web.
Hopefully the good people behind thunderbird, KDE apps etc have appetite to tackle this.