While originating in the browser as a P2P tech, using a Node WebRTC library can gain you server-side control for even better performance. At the really sophisticated end that can be intelligent routing and on-the-fly quality adjustments, so you're not just faster but smarter in delivering content.
I think WebRTC is essential for any real-time project, and coupling it with Node.js takes your tech stack from good to very good. We use it in BrowserBox to stream the viewport of a remote browser: https://github.com/BrowserBox/BrowserBox
For a low-latency gameserver where clients talk via PeerConnection, clients could talk to the server with the same code if it's authorative.
Recording/transcoding a multiuser video-chat session.
Possibly also Ice (helping clients connect to each other if they are behind firewalls)