Though personally, I don't see the need for e-ink except perhaps outdoors or in changing environments. Just setting the brightness at a decent value gives a good enough contrast; after all an e-ink display just reflects light so if the ambient lighting is constant you can just adjust your LED panel to that same overall brightness. I think the scrolling issues of e-ink would be a much greater source of eye strain and discomfort.
You can also use an off-white color as a background. Like HN does! It gives a similar feel as paper.