While acknowledging that I don't know whether I can tell the difference in every case or not, I would summarize my own preference for lossless audio in the following terms. Choosing lossy audio, my best case scenario is that I save space or bandwidth because I can't tell the difference; my worst case scenario is that I'm missing some element of the music, whether it is consciously noticeable, something I'm unaware of entirely, or perhaps something that I may only be experiencing on a somatic level that doesn't reach the level of conscious thought (I know that the possibility of this last option will be contested by some, and that's fair enough). Choosing lossless audio, my best case scenario is that I'm hearing the music in a higher fidelity, and increasing the amount I'm capable of appreciating; my worst case scenario is that I'm wasting some space or bandwidth for the reassurance. Basically, Pascal's Wager, but for audio.