hex
octal
binary
how to convert between the above 3, and between them and decimal
bit twiddling
the difference between ASCII and binary files (even pre-unicode)
the fact that a source code program compiled on one processor architecture will not run on another without recompilation on the target, apart from cross-compilation - at least in most cases this was true, though there might be differences nowadays, for apple products, java and other bytecode, etc.
endianness
...
I have actually talk to various people who did not know all of the above topics, although not necessarily all in the same person