I always default to AU just because I’m on a Mac and I arbitrarily decided to do so long ago. The Rosetta thing has been a nice bonus. Not sure what the other (dis)advantages are, these days I try to focus on using native Ableton and M4L stuff anyway!
Yes, this has been my experience with AUs in Logic Pro, at least. You simply get a message saying a plugin failed and that you can try reloading it if you'd like.
Apple Silicon macs can now run iOS / iPadOS AUs as well, so there are a ton of plugins from that world that are not available as VSTs.
Apple Logic can't load VSTs, so typically on the Mac it makes sense to just have AUs. Ableton Live on the Mac can load VSTs or AU, but there isn't really a reason to keep the VSTs around.