One of my daily drivers is a large (13.3") e-ink tablet. Reading on that is actually a pleasure, though it's led me to another conclusion: scrolling sucks.
I much prefer reading paginated media, and if at all possible, fixed-layout media (e.g., PDFs rather than ePub) both because the same material stays in the same place on the same page regardless of other settings (I have a strongly spatial memory), and because the layout is usually just simply much better than what fluid-layouts achieve.
What really drives me nuts though is having to scroll on webpages. It's imprecise, half the time I'm clicking on something I'd not intended to, and it's much harder and less pleasing to read.
But size and print clarity alone make this a huge improvement over smartphone displays.
Sorry to hear about the eyesight issues.