https://instagram-engineering.com/types-for-python-http-apis...
https://engineering.fb.com/2023/09/07/culture/threads-inside...
https://engineering.fb.com/2022/05/02/open-source/cinder-jit...
https://engineering.fb.com/?s=django
Django is also excellent for e-commerce with projects like https://github.com/saleor/saleor - or you can roll your own e-commerce system quite easily, which we've done at my travel startup.
Here in Seattle, Rover (a $1B+ market cap company) also uses Django extensively. As do lots of interesting local startups.
To the larger point about Django and e-commerce, though, I'll share that we do a large volume of complex transactions where multiple funds flows for different parties need to be coordinated, so it's been vital to be able to have a dynamic data model to track the payables/receivables lifecycle of a given booking and add overrides/configurability to handle unique situations as they come along. Django's been a perfect match for that, the framework source code is very approachable (IMO much less "magical" than Rails in this regard while having the same level of expressivity and shorthand), and since it's Python, it works extremely well with data science tooling as well.
One of the many more complex sites we've used it to build is https://www.business-humanrights.org/en/ which tracks over 10k companies, 100k+ articles in 15 or so languages. We've also built internal dashboards, live updating forums, donations platforms and so on. Another interesting one might be https://www.achurchnearyou.com/ which is used by the church of England to provide "mini sites" for all their congregations around England, so several thousand church administrators use that every week.