"But I also think Lisp leads to spectacular burnout as I think it imposes a greater cognitive requirement on the part of the developer."
I have never heard about this as a speciality of Lisp.
> there's a very strong case that Symbolics did outperform others with their software productivity
Symbolics used object-oriented programming in the form of Flavors. It had an integrated, GUI-based development environment. Development was mostly incremental: one can write some piece and run it immediately inside the application under development. Everything runs in a debug mode, without an explicit debug mode. The whole system, the whole documentation, the whole source code was always available. The applications were large, but for today's standards nothing shockingly large.
But there were also downsides. Mostly: hardware developed outside much faster and software had to move there.
First the Symbolics graphics suite was ported over to SGIs running Allegro CL, then also Windows NT systems. A refresh of the graphics suite was developed under the name Mirai.
https://www.youtube.com/watch?v=UNXEemZ_Ysk