Depends on the implementation? For many services, I register my Yubikey, but also the Android fingerprint authentication (as well as TOTP as another fallback).

So for example, if I login to Gitlab on my phone, I can use my fingerprint (lockscreen auth). It's more convenient than using the TOTP app.

Similarly, I could register a TPM from my desktop that could be the same as using the fingerprint auth? It would only work from that desktop, but it's the same logic as my phone, and in a sense, that's a nice benefit.