To be clear, we're only against ticketing systems that worsen the experience for the user. Ticketing systems on the backend are great, but having an automated mail system spew at you is a less-than-ideal experience. Email from real humans is what I want as a user of a support system.
I would love to know what you think of our approach to customer support at http://supportbee.com. We have focused on simplicity and making sure that to a customer everything looks just like regular email.