What does happen is that companies with local agent networks or partners will engage that local partner. NYC is large enough that all sorts of unusual capability exists. If you need to get a bunch of farm animals in midtown, there are in-region companies who can do that.
Companies that don’t have appropriate supply chain ops just aren’t going to effectively do business. If in-region to you means a DC in North Carolina, for example, you’re probably going to get eaten alive by the competition.