This is hard to explain but my experience with my Kinesis Advantage is that the keys above the home row and especially the function keys (really just function buttons) are too high and are oriented with the faces of these keys too angled towards my hands (i.e. the normal vector from the top of the keycaps are angled at perhaps 45 degrees from vertical). So on an "ordinary" keyboard, like a laptop keyboard, the surface of the keycaps are roughly parallel to the surface of the laptop keyboard. On such an ordinary keyboard it is quite easy to press the number keys and function keys without a lot of finger flexing, while on the Kinesis Advantage I feel like I am curling my fingers then lifting my whole hand and then straightening my fingers to kind of punch the keys like one would press a button mounted on a wall. (Does this elaborate explanation even make sense or am I just being picky?)
I greatly prefer typing on the Kinesis Gaming Keyboard. These feel better than using welled keyboards to me.