My .bashrc script (when logging on, which is checked by the fact that no GUI session is running) starts X Window (actually it starts an XFCE session, because that is what I use), then it remaps the keyboard to a custom Dvorak variant and it configures Wacom thus:

WACOM_ID=$(xsetwacom list | grep STYLUS | cut -f 2 | cut -d " " -f 2)

xsetwacom set "$WACOM_ID" "Button" "2" "button +3 "

xsetwacom set "$WACOM_ID" "Button" "3" "button +1 -1 +1 -1 "

xsetwacom set "$WACOM_ID" "Mode" "Relative"

The line that discovers WACOM_ID is necessary because the Wacom device driver does not always use the same device numbers, even when nothing has been inserted or extracted in or from the USB ports. Moreover, even the Wacom subdevices are not always listed in the same order, hence the need to use grep for row select.

There are many other ways to execute a script on startup, where you can add these lines.

The acceleration of the Wacom mouse cursor is configured in the standard desktop settings.

"button +3 " means that the associated action is right click.

"button +1 -1 +1 -1 " means that the associated action is left double click.

I have left the default action for touching the tablet with the pen, which is left click. Selection by pointing and touching is even more natural than with a mouse or other alternatives.

I believe Wacom is a first class citizen in Linux. They have it in the kernel (https://linuxwacom.github.io/). There is also https://opentabletdriver.net/ that is multi-platform.