Personally, my wrists start to hurt after only an hour or two of use of a "normal" keyboard and mouse. It doesn't matter if I've spent the previous 3 months offline doing yoga (getting very thorough full-body movement) or totally absorbed in some computer-y project - "normal" input devices hurt! My shoulders and back are more tolerant, but eventually they start to ache too.
It's likely I didn't take care of myself properly earlier in life, but using a split keyboard and tilted thumb-operated trackball mean I can continue coding without nerve pain.
To be clear, the goal is not exactly to move less - it's to keep the wrists and shoulders in a neutral, less-stressful position.