Im not even sure how to go about prototyping this, not without spending a lot of money to get there. Not a glove, but more like a custom formed mouse shell, thats at least as big as the users hand.

Theres definitely a market for it. People have made all kinds of ridiculous mods for their mice to make it comfortable, and then theres mice that come with a billion parts that allow customization for your comfort. This would give a better option, and allow choice of mouse based on pure performance, instead of having to compromise because of feel or comfort. As far as i know, nothing like this is being done for mice, but the technology to make it already exists in other markets