- An EMP would wipe-out unprotected electronics easily
- Targeted energy weapons could fry sensors or the whole ship - The frequencies it uses can be jammed
- A Barrett .50, on the ground or out of a helicopter, could vaporize one of these
- A seemingly normal airplane could "accidentally" ram it
- A similar airplane could use a net and capture it, leaving no evidence
- Hell, if it flies high enough, its onboard GPS device might self-deactivate due to US law.