Considering Jeff Foxworthy has sold over 15 million albums[1], recently had a primetime show in syndication, and managed to make three of his drinking buddies into 8-figure yearly draws, I would say Louis CK is not even close to the most popular working comedian around. He has a rabid base, yes, but I would argue he's not even a mainstream comic (ie I would bet 9/10 people off the street would not know who he is).
I think this bodes very well for those who can mobilize a few hundred thousand people. What I think will be even more interesting is how this will affect those that can only mobilize a few thousand.
[1]http://www.slate.com/articles/arts/number_1/2005/04/jeff_fox...