Sure, I'd love to learn that some sort of inscrutable aliens on the surface of a neutron star (https://gwern.net/doc/science/1973-drake.pdf) or gasbags on Jupiter (1. Sagan, C., and Salpeter, E. E. "Particles, Environments and Possible Ecologies in the Jovian Atmosphere," Astrophysical Journal Supplement, 32, 737 (1976).) to creatures that leave in witch space.

We simply don't have a framework other than basic physics and chemistry to speculate in this area. The possibility space is too large and we don't know the fitness function.