In Europe, the new Unified Patent Court (UPC) will probably rubberstamp them, using the "as such" and the "technical effect" loopholes. Without any appeal possible to the European Court of Justice.
For example, LoRa uses spread spectrum and there are many patents on spread sprectrum in general (don't know about LoRa in particular).
Heck, in the middle ground between "one-click shopping" and LoRa modulation, you have things like audio and video codecs. These are primarily math-based patents, but they have had pretty broad patent protection for a long time compared to more abstract business-process/software patents. Where this might get interesting specifically for LoRa is that France is one of the rare places that doesn't seem to recognize AV codecs as patentable (and which is why VLC is distributed from France) and Semtech is based out of Grenoble!