Yes. And as a point of reference for the scales involved:
> Since major groundwater pumping began in the late 1940s, overdraft from the High Plains Aquifer has amounted to 332,000,000 acre-feet (410 km3), 85% of the volume of Lake Erie. [1]
> The Mississippi River passes more than 240 million acre-feet annually at the proposed point of diversion, 30 miles south of Cairo, Ill. During the current flooding, more than 4 million acre-feet per day are flowing at that spot… [2]
The water in the Mississippi river could each year replace all 80 years of overpumping of the aquifer. So with 1-2% water diversion (like I said, not exhausting the river), you could easily substitute that volumetrically. For 5% you could massively irrigate the midwest.
These are truly massive rivers. People in the west don't understand how enormous they are compared to the Colorado and other western rivers.
[1] https://en.wikipedia.org/wiki/Ogallala_Aquifer#:~:text=Since....
[2] https://coyotegulch.blog/2011/05/19/pipeline-from-the-missis...